产品货号:jlcR3867 英文名称 :RGS19 中文名称 :G蛋白信号转导调节因子19抗体 别 名 :G alpha interacting protein; GAIP; GNAI3IP; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; Regulator of G protein signalling 19; RGSGAIP; RGS19_HUMAN; Regulator of G-protein signaling 19; RGS19; G-alpha-interacting protein. 研究领域 :肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 抗体来源 :Rabbit 克隆类型 :Polyclonal 交叉反应 : Human, Mouse, Rat, 产品应用 :WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 :25kDa 细胞定位 :细胞膜 性 状 :Lyophilized or Liquid 浓 度 :1mg/ml 免 疫 原 :KLH conjugated synthetic peptide derived from human RGS19:/101-200/217 亚 型 :IgG 纯化方法 :affinity purified by Protein A 储 存 液 :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 :Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed :PubMed 产品介绍 :G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase activating protein that functions to down regulate Galpha i/Galpha q linked signaling.
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Subunit: Interacts with GIPC PDZ domain.
Subcellular Location: Membrane; Lipid-anchor.
Tissue Specificity: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
Post-translational modifications: Fatty acylated. Heavily palmitoylated in the cysteine string motif. Phosphorylated, mainly on serine residues.
Similarity: Contains 1 RGS domain.
SWISS: P49795
Gene ID: 10287
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.