重组人sRANK Receptor现货供应

特别提示：包括重组人sRANK Receptor在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人sRANK Receptor
英文名称：Recombinant Human soluble Receptor Activator of Nuclear Factor kappa-B Receptor
产品货号：GS4664
产品规格：20μg

分子量：Approximately 19.1kDa,a single non-glycosylated polypeptide chain containing 174 amino acids.
储存条件：冷冻（-20℃）

概述

RANK Ligand and RANK Receptor are members of the TNF superfamily that play an important role in the regulation of specific immunity and bone turnover.RANK Receptor was originally identified as a dendritic-cell-membrane protein,which by interacting with RANKL augments the ability of dendritic cells to stimulate na?ve T cell proliferation and to promote the survival of RANK + T cells.RANK is also expressed in a variety of tissues including skeletal muscle,thymus,liver,colon,small intestine and adrenal gland.The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses.Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone(PDB2).Recombinant human sRANK receptor is a 19.1 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor(174 amino acid residues).

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞98%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B(NFkappaB)in RAW 264.7 cells is less than 50ng/ml,corresponding to a specific activity of>2.0×104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 20mMTris-HCl,pH 8.0,150mM NaCl.
内毒素	Less than 0.1 EU/μg of rHusRANK Receptor as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	QIAPPCTSEK HYEHLGRCCN KCEPGKYMSS KCTTTSDSVC LPCGPDEYLD SWNEEDKCLL HKVCDTGKAL VAVVAGNSTT PRRCACTAGY HWSQDCECCR RNTECAPGLG AQHPLQLNKD TVCKPCLAGY FSDAFSSTDK CRPWTNCTFL GKRVEHHGTE KSDAVCSSSL PARK

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