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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
23
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
SPECA
- 抗体名：
a-包衬蛋白抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul/200ul
| 规格： | 100ul | 产品价格： | ¥1580.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ¥2480.0 |
英文名称 : SPECA
中文名称 : a-包衬蛋白抗体
别 名 : Fodrin alpha chain; (ALPHA)II-SPECTRIN; Alpha II Spectrin; FLJ44613; Fodrin, alpha; NEAS; Non erythrocytic spectrin alpha; SPECA; Spectrin alpha chain; Spectrin alpha chain brain; Spectrin alpha non erythrocytic 1; Spectrin non erythroid alpha chain; Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Spectrin, nonerythroid, alpha subunit; Spna2; SPTA 2; SPTA2; SPTAN 1; SPTAN1; SPTA1_HUMAN.
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 284kDa
细胞定位 : 细胞浆 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human SPECA:551-650/2472
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : a-Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.
Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Subunit:
Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM and EMD. Interacts (via C-terminal spectrin repeats) with TRPC4. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1.
Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
Post-translational modifications:
Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro
DISEASE:
Defects in SPTAN1 are the cause of epileptic encephalopathy early infantile type 5 (EIEE5) [MIM:613477]. EIEE5 is a disorder characterized by seizures associated with hypsarrhythmia profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia.
Similarity:
Belongs to the spectrin family.
Contains 3 EF-hand domains.
Contains 1 SH3 domain.
Contains 23 spectrin repeats.
SWISS:
Q13813
Gene ID:
6709
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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文献和实验垫是否老化、变质，造成漏泄； 5.摆杆、弹簧、球面垫圈是否有破损、卡死现象； 6.各连接件是否松动、腐蚀，衬包层是否破裂； 7.转鼓是否变形、腐蚀，特别是纵焊缝的腐蚀状况，若出现焊缝明显减薄或呈黑色蜂窝状微孔组织、焊缝与母材界面有明显裂纹，敲击焊缝已无金属声等现象，应立即停止使用。对于包衬有橡胶或塑料等衬层的转鼓，更应经常检查衬层状态，以免由于衬层裂缝、孔眼等的渗液，造成内层金属的急剧腐蚀。 三、根据检查结果，决定清洗、换件或修复。若转鼓严重变形或腐蚀，转动部位严重磨损，应进行大修或换件
质。 6.称量包装：(1)包装规格：包装体积不带草袋70×40×(25～30)厘米，淡干每包净重40千克，咸干每包净重50千克。 (2)包装及质量标志：海带要用包装机压实，先捆上两条绳子，再用草袋包好，封口处应用麻袋线缝好，皮外再用绳子以“井”字形扎牢；皮上要用毛笔写上一、二、三……以代表一级、二级、三级、……不列等一级、不列等二级；淡干品用黑色标志，盐干品用红色标志；包内外要有质量卡片和标签，注明品名、等级、产地等。 附：盐干海带制法：1.腌制工具与场所的选择：腌制时，采用鱼
眼球壁及其内容的作用，前1/6叫做角膜cornea，是致密面透明的膜，其曲度大于眼球壁的其它部分，有屈光作用。角膜内无血管，但有大量的感觉神经末稍分布，对痛、触觉极为敏锐，故当炎症时常有剧痛。后5/6叫做巩膜sclera，呈乳白色，不透明，巩膜前端与角膜相续部分的深部，生有环形的静脉窦，叫做巩膜静脉窦sinus venosus sclerae ，后端在视神经穿 出部位，巩膜包于视神经的周围，形成视神经鞘。 图10-24 眼球的构造 （二）中膜
