重组人Amphiregulin北京现货

特别提示：包括重组人Amphiregulin在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人Amphiregulin
英文名称：Recombinant Human Amphiregulin
产品货号：GS4549
产品规格：10μg

分子量：Approximately 11.3kDa,a single non-glycosylated polypeptide chain containing 98 amino acid residues.
储存条件：冷冻（-20℃）

概述

Amphiregulin is an EGF related growth factor and was originally isolated from the conditioned media of a PMA-treated MCF-7 human breast carcinoma cell line.It is mainly expressed numerous carcinoma cell lines and the epithelial cells of various human tissues including colon,stomach,breast,ovary,kidney,etc.Synthesized as a transmembrane protein,Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein.There are 6 conserved cysteine residues,which form 3 intramolecular disulfide bonds essential for biological activity.Amphiregulin signals through the EGF/TGF-a receptor,and stimulates growth of keratinocytes,epithelial cells and some fibroblasts.It also inhibits the growth of certain carcinoma cell lines.Mutations in this encoded protein are associated with a psoriasis-like skin phenotype.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is between 5-10ng/ml.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuAmphiregulin as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK

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