Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).
产品描述
anti-USP37 antibody is a Rabbit Polyclonal antibody againstUSP37..
建议稀释比例
WB : 1:500-1:5000;IP:1:200-1:2000
IHC
Western blot
HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab09330(USP37 antibody) at dilution of 1:500(本抗体仅供体外科研用途,不可用于临床诊断!)