- ￥2262
- LSM Bio
- 进口
- PAab08878
- 2025年07月08日
- ELISA,IHC,IP,WB,IF
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
tumor protein p53
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,IHC,IP,WB,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
tumor protein p53
- 抗体英文名：
anti-TP53 antibody,TP53 antibody
- 抗体名：
anti-TP53 抗体,TP53 抗体
- 规格：
100μg
TP53抗体| TP53 antibody
货号 PAab08878
蛋白别名 P53
蛋白介绍
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1- mediated transcriptional activation of PER2 (PubMed:24051492).
产品描述
anti-TP53 antibody is a Rabbit Polyclonal antibody againstTP53..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human endometrial cancer using PAab08878(P53 antibody) at dilution of 1:100
Western blot
MCF7 cells were subjected to SDS PAGE followed by western blot with PAab08878(P53 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验Science：直击肿瘤命门，Shibin Zhou 等开发靶向 TP53 突变的双特异性抗体
p53 基因是人体内最重要的抑癌基因之一，扮演着人体基因组守护者的角色。 p53 缺失会使得表达致癌基因的细胞无限增殖，从而直接导致癌症发生；p53 缺失还会导致存活的子代细胞中基因突变负荷增加，间接地促进癌症的发生。编码 p53 的 TP53 基因也是人类癌症中最常出现突变的抑癌基因。因此，一般认为，TP53 基因的突变常常与癌症的发生和患者的不良预后相关 [1]。 关于 TP53 基因的研究一直是肿瘤治疗领域的热点，科学家们也一直在苦苦探寻靶向 TP53 的肿瘤治疗药物，但是至今还没有针
免疫细胞可识别并杀伤有害的靶细胞（如突发性肿瘤细胞），是人体宿主防御机制的一个重要组成部分。抗体依赖性细胞介导的细胞毒性 (ADCC) 和 T 细胞杀伤是细胞介导的免疫应答的两种机制，其中的每个过程都涉及刺激免疫细胞亚群（例如，自然杀伤 (NK) 细胞或细胞毒性 T 淋巴细胞 (CTL)），使它们主动裂解靶细胞。 近期，约翰霍普金斯大学医学院的研究人员在Science期刊发表研究成果[1]。他们发现了靶向TP53突变的新抗原，筛选出一种抗体片段（H2-scFv）特异性识别灭活的肿瘤
TP53 Mutation Detection by SSCP and Sequencing
The TP53 tumor suppressor gene on chromosome 17p13.1 contains 11 exons and encodes a nuclear phosphoprotein of 53 kDa, a transcription factor involved in the regulation of the cell cycle (1 ). Normal p53 protein functions as a cell cycle
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