PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
克隆性:
单克隆
适应物种:
Human,Mouse ,Rat
保质期:
12 month
库存:
50
供应商:
LSM bio
宿主:
Rabbit
应用范围:
ELISA,IHC,IP,WB,IF
浓度:
≥95% as determined by SDS-PAGE
抗体英文名:
anti-TP53 antibody,TP53 antibody
抗体名:
anti-TP53 抗体,TP53 抗体
规格:
100μg
TP53抗体| TP53 antibody
货号 PAab08878
蛋白别名 P53
蛋白介绍
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1- mediated transcriptional activation of PER2 (PubMed:24051492).
产品描述
anti-TP53 antibody is a Rabbit Polyclonal antibody againstTP53..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human endometrial cancer using PAab08878(P53 antibody) at dilution of 1:100
Western blot
MCF7 cells were subjected to SDS PAGE followed by western blot with PAab08878(P53 antibody) at dilution of 1:1000(本抗体仅供体外科研用途,不可用于临床诊断!)