signal transducer and activator of transcription 3 (acute-phase response factor)
亚型:
IgG
形态:
liquid
保存条件:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
克隆性:
单克隆
适应物种:
Human, Mouse
保质期:
12 month
库存:
50
供应商:
LSM bio
宿主:
Rabbit
应用范围:
ELISA,WB,IHC,IP
浓度:
≥95% as determined by SDS-PAGE
抗体英文名:
anti-STAT3 antibody,STAT3 antibody
抗体名:
anti-STAT3 抗体,STAT3 抗体
规格:
100μg
STAT3抗体| STAT3 antibody
货号 PAab08299
蛋白别名 APRF
蛋白介绍
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.
产品描述
anti-STAT3 antibody is a Rabbit Polyclonal antibody againstSTAT3..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human cervical cancer using PAab08299(STAT3 antibody) at dilution of 1:100
Western blot
K-562 cells were subjected to SDS PAGE followed by western blot with PAab08299(STAT3 antibody) at dilution of 1:500(本抗体仅供体外科研用途,不可用于临床诊断!)