PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
克隆性:
单克隆
适应物种:
Human,Mouse ,Rat
保质期:
12 month
库存:
50
供应商:
LSM bio
宿主:
Rabbit
应用范围:
ELISA,WB,IHC
浓度:
≥95% as determined by SDS-PAGE
抗体英文名:
anti-SNX6 antibody,SNX6 antibody
抗体名:
anti-SNX6 抗体,SNX6 抗体
规格:
100μg
SNX6抗体| SNX6 antibody
货号 PAab08095
蛋白别名
蛋白介绍
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).
产品描述
anti-SNX6 antibody is a Rabbit Polyclonal antibody againstSNX6..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human heart slide using PAab08095( SNX6 Antibody) at dilution of 1:50
Western blot
RAW 264.7 cells were subjected to SDS PAGE followed by western blot with PAab08095( SNX6 Antibody) at dilution of 1:600(本抗体仅供体外科研用途,不可用于临床诊断!)