- ￥2262
- LSM Bio
- 进口
- PAab06935
- 2025年07月16日
- ELISA,WB,IHC,IP
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
protein tyrosine phosphatase, non-receptor type 2
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
protein tyrosine phosphatase, non-receptor type 2
- 抗体英文名：
anti-PTPN2 antibody,PTPN2 antibody
- 抗体名：
anti-PTPN2 抗体,PTPN2 抗体
- 规格：
100μg
PTPN2抗体| PTPN2 antibody
货号 PAab06935
蛋白别名 PTPT
蛋白介绍
Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA.
产品描述
anti-PTPN2 antibody is a Rabbit Polyclonal antibody againstPTPN2..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human colon cancer using PAab06935(PTPN2 antibody) at dilution of 1:50
Western blot
mouse thymus tissue were subjected to SDS PAGE followed by western blot with PAab06935(PTPN2 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验免疫疗法大升级！迟洪波课题组发现延长 T 细胞存活的关键蛋白
，与此同时还发现了 PTPN2 和 SOCS1 两个具有协同作用的靶点。该研究有望极大程度地提高相关肿瘤免疫疗法的治疗效果。图片来源: Nature研究内容图片来源: Nature由于此前的研究报道细胞代谢与癌症免疫治疗中的 T 细胞寿命关系密切，研究人员使用 CRISPR–Cas9 诱变筛选技术靶向了 OT-I Τ 细胞中 3017 个代谢相关的基因，在过继到患癌小鼠后，从小鼠的 B16 黑色素瘤中得到肿瘤浸润性淋巴细胞（tumour-infiltrating lymphocytes，TIL
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