- ￥2262
- LSM Bio
- 进口
- PAab06602
- 2025年07月11日
- ELISA,WB,IHC,IF,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
protein O-fucosyltransferase 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
protein O-fucosyltransferase 1
- 抗体英文名：
anti-POFUT1 antibody,POFUT1 antibody
- 抗体名：
anti-POFUT1 抗体,POFUT1 抗体
- 规格：
100μg
POFUT1抗体| POFUT1 antibody
货号 PAab06602
蛋白别名 FUT12 antibody, KIAA0180
蛋白介绍
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).
产品描述
anti-POFUT1 antibody is a Rabbit Polyclonal antibody againstPOFUT1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human liver cancer using PAab06602(POFUT1 antibody) at dilution of 1:50
Western blot
HepG2 cells were subjected to SDS PAGE followed by western blot with PAab06602(POFUT1 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验-fucosylation and O -glucosylation. We have identified the glycosyltransferases that catalyze the addition of the first sugar to these consensus sites: protein O -fucosyltransferase 1 (Pofut1) and protein O -glucosyltransferase (Rumi/Poglut1). Recently
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