PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
克隆性:
单克隆
适应物种:
Human,Mouse ,Rat
保质期:
12 month
库存:
50
供应商:
LSM bio
宿主:
Rabbit
应用范围:
ELISA,WB,IHC,IF,IP
浓度:
≥95% as determined by SDS-PAGE
抗体英文名:
anti-POFUT1 antibody,POFUT1 antibody
抗体名:
anti-POFUT1 抗体,POFUT1 抗体
规格:
100μg
POFUT1抗体| POFUT1 antibody
货号 PAab06602
蛋白别名 FUT12 antibody, KIAA0180
蛋白介绍
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).
产品描述
anti-POFUT1 antibody is a Rabbit Polyclonal antibody againstPOFUT1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human liver cancer using PAab06602(POFUT1 antibody) at dilution of 1:50
Western blot
HepG2 cells were subjected to SDS PAGE followed by western blot with PAab06602(POFUT1 antibody) at dilution of 1:500(本抗体仅供体外科研用途,不可用于临床诊断!)