- ￥2262
- LSM Bio
- 进口
- PAab06449
- 2025年07月15日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
phosphoinositide-3-kinase, class 2, alpha polypeptide
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
phosphoinositide-3-kinase, class 2, alpha polypeptide
- 抗体英文名：
anti-PIK3C2A antibody,PIK3C2A antibody
- 抗体名：
anti-PIK3C2A 抗体,PIK3C2A 抗体
- 规格：
100μg
PIK3C2A抗体| PIK3C2A antibody
货号 PAab06449
蛋白别名
蛋白介绍
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin- mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin- independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.
产品描述
anti-PIK3C2A antibody is a Rabbit Polyclonal antibody againstPIK3C2A..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human heart using PAab06449(PIK3C2A antibody) at dilution of 1:50
Western blot
PC-3 cells were subjected to SDS PAGE followed by western blot with PAab06449(PIK3C2A antibody) at dilution of 1:1500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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