- ￥2262
- LSM Bio
- 进口
- PAab06279
- 2025年07月13日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
pyruvate dehydrogenase kinase, isozyme 4
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
pyruvate dehydrogenase kinase, isozyme 4
- 抗体英文名：
anti-PDK4 antibody,PDK4 antibody
- 抗体名：
anti-PDK4 抗体,PDK4 抗体
- 规格：
100μl
PDK4抗体| PDK4 antibody
货号 PAab06279
蛋白别名 PDHK4
蛋白介绍
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
产品描述
anti-PDK4 antibody is a Rabbit Polyclonal antibody againstPDK4..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human kidney using PAab06279(PDK4 antibody) at dilution of 1:50
Western blot
mouse heart tissue were subjected to SDS PAGE followed by western blot with PAab06279(PDK4 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验饥饿使人健康又长寿？新研究揭示，减少热量摄入还不够，适当「饿肚子」或是发挥作用的关键
通路相关的基因表达改变，比如下调酪氨酸羟化酶 D5 受体（多巴胺受体）的基因表达。 CR 和 CD 组之间并没有发现相关神经肽表达的差异，尽管两组相对于 CT 组，它们都显示出促食欲神经肽 NPY 和 AgRP 的基因表达增加，并且 POMC 和 CART 的水平降低。但是两者也存在相对细小的差异，我们发现 16 个基因在 CR 里相对于 CD 上调，同时还有另外 16 个基因相对下调。但 CR 相对于 CD 的上调基因里包括许多在饥饿时表达会增强的基因如 Hif3、Tsc22d3、pdk4
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