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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
phosphodiesterase 3B, cGMP-inhibited
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
Q9WVH4
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,IP
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
phosphodiesterase 3B, cGMP-inhibited
- 抗体英文名:
anti-PDE3B antibody,PDE3B antibody
- 抗体名:
anti-PDE3B 抗体,PDE3B 抗体
- 规格:
100μl
PDE3B抗体| PDE3B antibody
货号 PAab06252
蛋白别名
蛋白介绍
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
产品描述
anti-PDE3B antibody is a Rabbit Polyclonal antibody againstPDE3B..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途,不可用于临床诊断!) <"">
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文献和实验打破传统认知,降糖不仅依赖胰岛素!科学家发现,这种来自脂肪的激素也可以调节血糖……
P)、果糖 6-磷酸(F6P)、磷酸甘油酸(PG)、磷酸烯醇式丙酮酸(PEP)和草酰乙酸(OAA)显著降低,而参与三羧酸循环(TCA)的代谢物则没有受到影响。不过,这些糖异生底物的显著减少在 adR1KO 小鼠中并不存在,因此 FGF1 调节 HGP 也是需要 FGF1 受体的存在。 图片来源:Cell Metabolism 体内 FGF1 诱导的血糖降低依赖于 PDE4 胰岛素依赖 PI3K 通路激活 PDE3B 来抑制脂肪分解,FGFR1 的激活也可以通过 PI3K 通路发出信号,但有
Adenovirus-Mediated Overexpression of Murine Cyclic Nucleotide Phosphodiesterase 3B
with insulin (100 nM , 10 min) resulted in an approx 1.7-fold increase in endogenous PDE3B and recombinant wild-type PDE3B activities. Infection of rat pancreatic islets resulted in a 5- to 10-fold increase in PDE3B expression and activity and subsequent
(6 ) consists of two subfamilies, PDE3A and PDE3B , which exhibit tissue-specific distribution; grossly, PDE3A enzymes are expressed in the cardiovascular system, and PDE3B enzymes in insulin-sensitive cells, such as hepatocytes (7 ) and adipocytes
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