- ￥2262
- LSM Bio
- 进口
- PAab06239
- 2025年07月18日
- ELISA,WB,IHC,FC,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
programmed cell death 4 (neoplastic transformation inhibitor)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,FC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
programmed cell death 4 (neoplastic transformation inhibitor)
- 抗体英文名：
anti-PDCD4 antibody,PDCD4 antibody
- 抗体名：
anti-PDCD4 抗体,PDCD4 抗体
- 规格：
100μl
PDCD4抗体| PDCD4 antibody
货号 PAab06239
蛋白别名 H731
蛋白介绍
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
产品描述
anti-PDCD4 antibody is a Rabbit Polyclonal antibody againstPDCD4..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human breast cancer using PAab06239(PDCD4 antibody) at dilution of 1:50
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab06239(PDCD4 antibody) at dilution of 1:3000(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验【进展|热点】Nature Immunology:又一个调控天然免疫的microRNA
文章来源： http://www.nature.com/ni/journal/v11/n2/abs/ni.1828.html 题目: Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. 背景： 1，TLR4信号通路有很多负向调控因子，microRNA是其中的重要一员。 2，PDCD4也是重要的促炎因素
Nature Immunology:又一个调控天然免疫的microRNA
背景： 1、TLR4信号通路有很多负向调控因子，microRNA是其中的重要一员。 2、PDCD4也是重要的促炎因素（PDCD4缺失的小鼠对LPS有抗性）。 3、以往的研究发现 miR-21的靶点之一就是PDCD4。 内容概要： PS刺激可以引起PDCD4表达短暂增高，PDCD4表达增高具有两种意义：第一，通过结合于IL-10的mRNA，阻止延长因子与之结合而在翻译水平下调抗炎因子IL-10的表达；第二，通过抑制NF-κB上游分子IκBα的合成而增强NF-κB的活性，促进炎症介质IL
Combined MicroRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers
setting. In this chapter we present a fluorescence-based technology that allows the combination of microRNA in situ hybridization with immunohistochemistry exemplified by the in situ detection of miR-21 and miR-205 in combination with PDCD4 and smooth
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