- ￥2262
- LSM Bio
- 进口
- PAab06089
- 2025年07月18日
- ELISA,IHC,IF,IP,WB,FC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat,Pig
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat,Pig
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,IHC,IF,IP,WB,FC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
- 抗体英文名：
anti-p65/RELA antibody,p65/RELA antibody
- 抗体名：
anti-p65/RELA 抗体,p65/RELA 抗体
- 规格：
100μl
p65/RELA抗体| p65/RELA antibody
货号 PAab06089
蛋白别名 NFKB 3 antibody, NFKB p65 antibody, NFKB3 antibody, p65 antibody, RELA antibody, Transcription factor p65
蛋白介绍
Nuclear factor k B (NF-kB) is a sequence-specific DNA-binding protein complex which regulates the expression of viral genomes, including the human immunodeficiency virus, and a variety of cellular genes, particularly those involved in immune and inflammatory responses. The members of the NF-Kb family in mammalian cells include the proto-oncogene c-Rel,p50/p105 (NFkB1), p65 (RelA), p52/p100 (NFkB2), and RelB. All of these proteins share a conserved 300-amino acid region known as the Rel homology domain which is responsible for DNA binding, dimerization, and nuclear translocation of NF-Kb. The p65 subunit is a major component of NF-Kb complexes and is responsible for trans-activation. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. It associates with chromatin at the NF-kappa-B promoter region via association with DDX1. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human RELA.
产品描述
anti-p65/RELA antibody is a Rabbit Polyclonal antibody againstp65/RELA..
建议稀释比例
WB:1:500-1:5000;IP:1:500-1:5000;IHC:1:50-1:200;IF:1:10-1:100
IHC
Immunohistochemistry of paraffin-embedded human liver cancer using PAab06089(p65 antibody) at dilution of 1:50
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab06089(p65 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验Activation of Nuclear Factor-B (NF-B) in Mononuclear Cells (MNC)
is a heterodimer, which usually consists of two proteins, a p65 (relA) subunit and a p50 subunit. Other subunits (rel, relB, v-rel, and p52) can also bind to the activated NF-κB and thus can activate different sets of genes.
http://www.dxy.cn/bbs/actions/archive/post/4320752_1.html http://www.takara.com.cn/activeproducts/am_2_04.htm 3、提高检索能力，多读文献吧，你的问题含糊，答案只能如此了。 4、NF-κB由两类亚基形成同源或异源二聚体。一类亚基包括p65(也称RelA)、RelB和C-Rel；另一类亚基包括p50和p52。最常见的NF-κB亚基组成形式为p65/p50或p65/p65
光谱） 图5 三种染料分别检测EdU孵育2h的Hela细胞（40X） EdU细胞增殖检测方法不需要剧烈的DNA变性操作，只需温和的细胞固定化和透化处理，能够较好地保护细胞形态、DNA整体结构及细胞内抗原识别位点，更适合结合其他染料或蛋白标记（如P65抗体）等进行多重标记，从而在细胞水平获取更多的直观多维特征信息，更适合深入开展细胞功能方面的研究。 图6 结合P65抗体和EdU，分析药物对细胞增殖及NF-KB信号通路的影响 该方法无需DNA变性，无需抗原修复，无需抗原抗体反应，简单
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