- ￥2262
- LSM Bio
- 进口
- PAab06086
- 2025年07月17日
- ELISA,WB,IHC,IP,IF,FC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
sequestosome 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP,IF,FC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
sequestosome 1
- 抗体英文名：
anti-P62/SQSTM1 antibody,P62/SQSTM1 antibody
- 抗体名：
anti-P62/SQSTM1 抗体,P62/SQSTM1 抗体
- 规格：
100μl
P62/SQSTM1抗体| P62/SQSTM1 antibody
货号 PAab06086
蛋白别名 P62 antibody, sequestosome 1 antibody, SQSTM1 antibody, Ubiquitin binding protein p62
蛋白介绍
Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate, p62 is degraded during the autophagic process, which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases, including Huntington's disease, Alzheimer's disease, Parkinson's disease in the brain, and nephropathic cystinosis in kidney (22074114, 22860231, 22714671). The molecular weight of p62 is predicted as 48/ 38 kDa, while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.
产品描述
anti-P62/SQSTM1 antibody is a Rabbit Polyclonal antibody againstP62/SQSTM1..
建议稀释比例
WB:1:1000-1:10000;IP:1:1000-1:10000;IHC:1:20-1:200;IF:1:20-1:200
IHC
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using PAab06086( P62 SQSTM1 Antibody) at dilution of 1:50
Western blot
HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab06086(SQSTM1 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验Measurement of Autophagy in Cells and Tissues
3 by immunoblotting or immunofluorescence has become a reliable method for monitoring autophagy. When autophagy is impaired, the level of p62/SQSTM1, a ubiquitin- and LC3-binding protein, is increased in addition to the accumulation of ubiquitinated proteins
重磅综述：年发文量近 10000，自噬领域第 4 版研究指南发布
蛋白质使用相同的名称但不用斜体如 ULK1，而突变体则命名为 ULK1−/−。 第二，详细枚举整理了自噬的监测方法；指南列举了目前监测自噬几乎全部的方法，如①可通过透射电子显微镜观察到自噬体的形态结构，对所测自噬体大小和数量的计算推断自噬活性的强弱；②可对 Atg8 家族蛋白的检测与定量分析，Atg8 和 Atg8 家族蛋白是最广泛监测的自噬相关蛋白。本指南详细综述了利用这些蛋白质的多种分析方法；③通过 SQSTM1/p62 结合 LC3 蛋白翻转实验评价自噬流强弱；④对 TOR/MTOR, AMPK
a look from the following website just by clicking "Tyrosine Phosphorylation and Dimerization" http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-43F85YV-2&_user=1111158&_coverDate=06%2F29%2F2001&_rdoc=1&_fmt=full&_orig=search
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