- ￥2262
- LSM Bio
- 进口
- PAab05856
- 2025年07月14日
- ELISA,WB,IHC,IF,IP
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
neuregulin 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
neuregulin 1
- 抗体英文名：
anti-NRG1 antibody,NRG1 antibody
- 抗体名：
anti-NRG1 抗体,NRG1 抗体
- 规格：
100μl
NRG1抗体| NRG1 antibody
货号 PAab05856
蛋白别名 GGF antibody, HGL antibody, HRGA antibody, NDF antibody, SMDF
蛋白介绍
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).
产品描述
anti-NRG1 antibody is a Rabbit Polyclonal antibody againstNRG1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human breast cancer using PAab05856(NRG1 antibody) at dilution of 1:100
Western blot
human liver tissue were subjected to SDS PAGE followed by western blot with PAab05856(NRG1 antibody) at dilution of 1:250(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验Modeling Schizophrenia in Neuregulin 1 and ErbB4 Mutant Mice
. However, genetic studies have recently identified many susceptibility genes of this disorder including neuregulin 1 (NRG1 ) and its receptor ErbB4 . Arguably, relevant mutant mice have provided a unique opportunity to model “schizophrenia” in animals
神经调节蛋白基因之后，会重新获得保护层（protective layer）。 (Fig: Schematic Summary of Abnormalities in Nerves with Altered NRG1 Type III Levels) 参看英文原文： Neuregulin-1 Type III Determines the Ensheathment Fate of Axons Volume 47, Issue
三句话读懂一篇 CNS：秃头人的福音！口服药或可让毛发再生；中暑为何会导致死亡？中国团队找到了原因
躯体感觉是机体感知世界的重要途径。 2022 年 5 月 12 日，凯斯西储大学梅林教授实验室在 Neuron 杂志上发表研究论文 A novel spinal neuron connection for heat sensation。 该研究用热刺激小鼠皮肤，揭示了一个背角兴奋性中间神经元的新亚群，以共同编码的形式参与热痛觉信息传导，提示 NRG1-ErbB4 信号通路或是对痛觉干预的新靶点，对揭示抑郁症及精神分裂症相关的脑部疾病的机制提供了新线索！ 图 8: 来源 Neuron
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