- ￥2262
- LSM Bio
- 进口
- PAab05949
- 2025年07月13日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
2',5'-oligoadenylate synthetase 1, 40/46kDa
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
2',5'-oligoadenylate synthetase 1, 40/46kDa
- 抗体英文名：
anti-OAS1 antibody,OAS1 antibody
- 抗体名：
anti-OAS1 抗体,OAS1 抗体
- 规格：
100μl
OAS1抗体| OAS1 antibody
货号 PAab05949
蛋白别名 OIAS
蛋白介绍
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
产品描述
anti-OAS1 antibody is a Rabbit Polyclonal antibody againstOAS1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human liver tissue slide using PAab05949( OAS1 Antibody) at dilution of 1:200
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab05949(OAS1 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
<""> <""> <""> <""> <""> <"">风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Cell：「来骗来偷袭」剪接体靶向疗法「诱骗」机体，激活抗病毒免疫，让肿瘤自杀
传导以往研究表明，MYC 诱导的三阴性乳腺癌（triple-negative breast cancer，TNBC）对剪接体的基因扰动（genetic perturbation）很敏感，然而对剪接体抑制产生应答的途径仍然未知。基于此，作者首先对两个 MYC 诱导的 TNBC 细胞系 SUM159 和 LM2 的转录变化进行了表征，然后用小分子剪接体调节剂 SD6 进行处理。基因富集分析发现免疫信号通路（干扰素 α 和 β 信号通路）是正向富集最显著的途径，另外干扰素刺激基因 (如 OAS1、MX1
A. Perelygin, Andrey A. Zharkikh, Svetlana V. Scherbik and Margo A. Brinton (2006)The Mammalian 2′-5′ Oligoadenylate Synthetase Gene Family: Evidence for Concerted Evolution of Paralogous Oas1 Genes in Rodentia and Artiodactyla. Journal of Molecular Evolution
7, SUGT1, TSC1, TSC2. Response Proteins: AGT, BAD, BCL2L1, BCL2L11, BF, C3, COL1A1, CRP, CSN2, CXCL9, DUSP1, EIF4EBP1, ENPP2, FN1, G1P2, G1P3, GATA3, GBP1, HSPA5, HSPB1, IRS1, MAF, MMP3, MST1, NPPB, NOS3, OAS1, ORM1, PIN1, SAA1, SFN, SLC2A4, SRF, TERT
技术资料暂无技术资料 索取技术资料
