- ￥2650
- LSM Bio
- CHINA
- PAab05757
- 2025年07月11日
- ELISA,IHC,WB
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
NLR family, pyrin domain containing 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
- 克隆性：
单克隆
- 适应物种：
Human
- 保质期：
12 month
- 库存：
50
- 供应商：
LSM bio
- 宿主：
Rabbit
- 应用范围：
ELISA,IHC,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 抗体英文名：
anti-NLRP1 antibody,NLRP1 antibody
- 抗体名：
anti-NLRP1 抗体,NLRP1 抗体
- 规格：
100μg
NLRP1抗体| NLRP1 antibody
货号 PAab05757
蛋白别名 CARD7 antibody, DEFCAP antibody, KIAA0926 antibody, NAC antibody,
蛋白介绍
As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).
产品描述
anti-NLRP1 antibody is a Rabbit Polyclonal antibody againstNLRP1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human pancreas cancer using PAab05757(NLRP1 antibody) at dilution of 1:50
Western blot
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab05757( NLRP1 Antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!)
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文献和实验Reconstituting the NLRP1 Inflammasome In Vitro
, type 2 diabetes, gout, age-related macular degeneration) and neurological disorders (Alzheimer’s disease). Pathogen-stimulated NLRs such as NLR family Pyrin domain-containing protein 1 (NLRP1) assemble into molecular platforms called “inflammasomes
三句话读懂一篇 CNS：长期吃油腻高脂肪食物，更容易伤脑子；抑郁症患者为何更容易生病？
本周学术君继续带来 CNS 最新进展，助力大家勇攀科研高峰！ 1. Science：人 NLRP1 炎症小体活化新机制 含 NACHT, LRR 和 PYD 结构域蛋白简称 NLRPs，人类 NLRP1 可以感应双链病毒 RNA、病毒蛋白酶及 UVB 辐射。 2022 年 7 月 14 日，新加坡南洋理工大学的 Franklin L. Zhong 研究组在 Science 杂志上发表研究论文 ZAKa-driven ribotoxic stress response
Detection of Pyroptosis by Measuring Released Lactate Dehydrogenase Activity
Pyroptosis is a form of programmed, inflammatory cell death that is dependent on the activation of a cysteine protease caspase-1. Following caspase-1 activation via inflammasomes (including NLRP3, NLRC4, Nlrp1b, and AIM2), cells lose membrane
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