- ￥2062
- LSM Bio
- 进口
- PAab01769
- 2025年07月18日
- ELISA,WB,IP,IF
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
clock homolog ( Mouse )
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9GZT9
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IP,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
CLOCK
- 抗体英文名：
anti-CLOCK antibody,CLOCK antibody
- 抗体名：
anti-CLOCK 抗体,CLOCK 抗体
- 规格：
100μg
CLOCK抗体| CLOCK antibody
货号 PAab01769
蛋白别名 BHLHE8 antibody, KIAA0334
蛋白介绍
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner ARNTL/BMAL1. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK- ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1.
产品描述
anti-CLOCK antibody is a Rabbit Polyclonal antibody againstCLOCK..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!)
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文献和实验许多生物的活动有明显的日周期性，此周期性即使在黑暗或其它环境恒定的条件下出会持续很长的时间。另外，许多生物对光周期具有灵敏的反应（参见光周期性），可知生物对光期或暗期的长短能够察知。再有蜜蜂在与外界隔绝的恒温、恒光照之下，可以学会在每日的一定时刻集中到一定的饲喂地点（时间学习）。某种候鸟似乎根据在一定的时候太阳的位置而了解一定的方位。（参见太阳指针）。从这些情况看来，不可否认生物是有以某种方法察知时间的机制。这种生物体内存在的察知时间的机制称生物钟，也称体内钟。
动物体内决定生物时间节律的一种生物化学机制。室内和田间实验都已表明，很多动物行为的年节律、月节律和日节律都是由生物体内的生物钟控制的，在动物与外界环境隔离的情况下，各种行为节律仍然会表现出来。但在很多情况下，外部环境也存在着定时因素，它可保持生物钟节律和环境节律之间的同步性。当把动物与这种定时因素隔离时，动物的生物钟节律就会偏离环境节律。例如在固定不变的实验室条件下，蜥蜴仍能保持明显的日活动节律，这说明这种节律是内在的。但它又不是对外界温度和光照 24小时周期节律的一种
Identification of Clock Genes Using Difference Gel Electrophoresis
Proteomics is the study of the complete set of proteins encoded by the genome. The study of the proteome involves the investigation of changes in protein abundance, localization, involvement in multiprotein complexes, and detection
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