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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
v-raf murine sarcoma viral oncogene homolog B1
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human, Mouse
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
Q9GZT9
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
BRAF
- 抗体英文名:
anti-BRAF antibody,BRAF antibody
- 抗体名:
anti-BRAF 抗体,BRAF 抗体
- 规格:
100μg
BRAF抗体| BRAF antibody
货号 PAab00941
蛋白别名 BRAF1 antibody, RAFB1
蛋白介绍
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.
产品描述
anti-BRAF antibody is a Rabbit Polyclonal antibody againstBRAF..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human malignant melanoma tissue slide using PAab00941( BRAF Antibody) at dilution of 1:200
Western blot
(本抗体仅供体外科研用途,不可用于临床诊断!)
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文献和实验或可疑恶性患者的术后病理发现,仅20%~25%为甲状腺癌,而另75%~80%的患者则接受了不必要的甲状腺手术[3]。因此,如何正确处理这些FNAB无法确诊的病例,是目前面临的最大困难和挑战。 BRAF V600E是一个突出的PTC癌基因,占BRAF基因突变的80%,BRAF基因突变对PTC具有较好的特异性,BRAF突变阳性,几乎就可以确诊为PTC。因此,BRAF V600E对于乳头状甲状腺瘤来说是一种重要的诊断标记物,可以指导医师为细胞学诊断不能确诊的患者选择最佳的治疗方案。 表
Detecting Mechanisms of Acquired BRAF Inhibitor Resistance in Melanoma
V600 BRAF mutation was identified as an ideal target for clinical therapy due to its indispensable roles in supporting melanoma initiation and progression. Despite the fact that BRAF inhibitors (BRAFi) can elicit anti-tumor responses
Assaying for BRAF V600E in Tissue and Blood in Melanoma
The BrafV600E mutation has been detected in patients with metastatic melanoma, colon, thyroid, and other cancers. Studies suggested that tumors with this mutation are especially sensitive to BRAF inhibitors-hence the need to reliably
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