PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
克隆性:
单克隆
适应物种:
Human,Dog
保质期:
12 month
库存:
50
供应商:
LSM bio
宿主:
Mouse
应用范围:
ELISA,WB,IF
浓度:
≥95% as determined by SDS-PAGE
抗体英文名:
anti-BBS2 antibody,BBS2 antibody
抗体名:
anti-BBS2 抗体,BBS2 抗体
规格:
100μg
BBS2抗体| BBS2 antibody
货号 PAab00816
蛋白别名
蛋白介绍
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
产品描述
anti-BBS2 antibody is a Mouse Monoclonal antibody againstBBS2..