重组人MIC-A北京厂家

特别提示：包括重组人MIC-A在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人MIC-A
英文名称：Recombinant Human MHC Class I Polypeptide-Related Sequence A
产品货号：GS4896
产品规格：10μg

分子量：Approximately 32.8kDa,a single non-glycosylated polypeptide chain containing 285 amino acids.
储存条件：冷冻（-20℃）

概述

MIC-A(MHC class I chain-related gene A)is a single-pass type I member protein.It is expressed on the cell surface in gastric epithelium,endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes.Additionally,MIC-A can be induced by bacterial and viral infections.It shares 85%amino acid identity with MIC-B and they are distantly related to the MHC class I proteins.Because they possess three extracellular Ig-like domains,but unlike classical MHC class I molecules.They do not form a heterodimer with beta2 microglobulin,but bind as a monomer to a KLRK1/NKG2D that is an activating receptor expressed on NK cells,NKT cells,γδ T cells,and CD8+ αβ T cells.Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells.MIC-A recognition plays an important role in tumor surveillance,viral infections,and autoimmune diseases.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The specific activity is determined by binding MICA antibody in ELISA.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuMIC-A,His as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	EPHSLRYNLT VLSWDGSVQS GFLAEVHLDG QPFLRYDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEGLHSL QEIRVCEIHE DNSTRSSQHF YYDGELFLSQ NLETEEWTVP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR YLESGVVLRR TVPPMVNVTR SEASEGNITV TCRASSFYPR NIILTWRQDG VSLSHDTQQW G

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