- ￥1500 - 2500
- HUABIO
- ER1912-36
- 浙江杭州
- 2025年07月12日
- WB,IHC-P
- Rabbit
- Human, Mouse, Rat, Cow, Rabbit
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- 详细信息
- 文献和实验
- 技术资料
- 靶点：
LIMK1
- 浓度：
1 mg/mL.
- 应用范围：
WB,IHC-P
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Cow, Rabbit
- 保质期：
1年
- 供应商：
Huabio
- 标记物：
Non-conjugated
- 保存条件：
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 形态：
Liquid
- 亚型：
IgG
- 免疫原：
KLH conjugated synthetic peptide derived from human LIMK1 451-550/647
- 规格：
50μl/100μl
| 规格： | 50μl | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 100μl | 产品价格： | ￥2500.0 |
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.
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ER1912-36·Anti-LIMK1 Antibody
￥1500 - 2500
