重组人PPM1A报价

特别提示：包括重组人PPM1A在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人PPM1A
英文名称：Recombinant Human Protein Phosphatase 1A
产品货号：JN1661
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Gly2-Trp382在C端含有His标签。

PPM1A质量控制：＞95%(还原性SDS-PAGE)

PPM1A制剂：液体

PPM1A保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于PPM1A：
Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.

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