重组人NT-4北京供应商

特别提示：包括重组人NT-4在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人NT-4
英文名称：Recombinant Human Neurotrophin-4
产品货号：GS4492
产品规格：2μg

分子量：Approximately 28.1kDa,a noncovalently linked homodimer of two 14.0 kDa polypeptide monomers(262 total amino acid residues).
储存条件：冷冻（-20℃）

概述

NT-4 also named as NT-5 is a neuronal and epithelial grow factor belongs to the NGF-beta family.The NT-4 precursor is consisted of a 24 a.a.signal peptide,a 56 a.a.propertied and 130 a.a.NT-4.The mature protein has six Cys amino acid residues and has the relative structure with NT-3,BDNF(sharing about 48%- 52%sequence identity).Additionally,it shares 91%and 95%a.a.sequence identity with mouse and rat NT-4.NT-4 is mainly expressed in prostate and has low level thymus,placenta,and skeletal muscle.It can binding with the LNGFR and trkB receptors and plays a crucial role in the regulation of survival and the maintenance of peripheral sensory sympathetic neurons.Defect of NT-4 may cause primary open angle glaucoma type 1O.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures is less than 50ng/ml,corresponding to a specific activity of>2.0×104 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 5.5.
内毒素	Less than 1 EU/μg of rHuNT-4 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A

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