重组人FGF-23北京品牌

特别提示：包括重组人FGF-23在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人FGF-23
英文名称：Recombinant Human Fibroblast Growth Factor-23
产品货号：GS4547
产品规格：5μg

分子量：Approximately 25.3kDa,a single non-glycosylated polypeptide chain containing 227 amino acids.
储存条件：冷冻（-20℃）

概述

Human FGF-23 belongs to the FGF-19 subfamily which has three members FGF-19,21,23.All FGF family members are heparin binding growth factors with a core 120 amino acid(a.a.)FGF domain that allows for a common tertiary structure.They are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis.By contrast,the FGF-19 subfamily has recently been shown to function in an endocrine manner.Members of this subfamily have poor ability of binding to heparin binding site which is a crucial factor in ligand-receptor complex formation.β-Klotho has been identified as co-factor required for FGF-19,21,23 signaling.It can obviously increase ligand-receptor affinity.FGF-23 is most highly expressed in bone,from which it circulates through the blood to regulate vitamin D and phosphate metabolism in kidney.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5μg/ml,corresponding to a specific activity of>2.0×103 IU/mg in the presence of 0.3 μg/ml of rMuKlotho and 10 μg/ml of heparin.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuFGF-23 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI

我公司销售的重组人FGF-23北京品牌，重组Fibroblast Growth Factor-23，重组人Fibroblast Growth Factor-23，FGF-23, Human，Recombinant Human Fibroblast Growth Factor-23质量上佳，价格普惠，欢迎广大新老客户踊跃订购。