重组人细胞周期蛋白H(CCNH)价格

特别提示：包括重组人细胞周期蛋白H(CCNH)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人细胞周期蛋白H(CCNH)
英文名称：Recombinant Human Cyclin-H
产品货号：JN1347
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Leu323在N端含有His标签。

CCNH质量控制：＞95%(还原性SDS-PAGE)

CCNH制剂：液体

CCNH保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于CCNH：
Human CCNH, also known as Cyclin-H，MO15-associated protein，p34 and p37, is a protein which belongs to the highly conserved cyclin family. Cyclin family members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1.CCNH regulates CDK7 which is the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. CCNH is also involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

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