GSK3145095,1622849-43-7

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GSK3145095

CAS No. : 1622849-43-7

MCE 国际站：GSK3145095

产品活性：GSK3145095 是一种 RIP1 激酶抑制剂，其 IC₅₀ 值为 6.3 nM 。

研究领域：Apoptosis

作用靶点：RIP kinase

In Vitro: GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC₅₀ = 1.6 nM), cell death as measured by LDH release (IC₅₀ = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC₅₀ = 0.4 nM) .

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