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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
328565-16-8
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥363.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1350.0 |
| 规格： | 25 mg | 产品价格： | ￥2800.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
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Col003
CAS No. : 328565-16-8
MCE 国际站：Col003
产品活性：Col003 是 Hsp47 的选择性有效抑制剂，竞争性结合的胶原蛋白结合位点 Hsp47 (IC50，1.8 μM)。Col003 抑制 Hsp47 与胶原蛋白的相互作用，通过破坏胶原蛋白三螺旋的稳定性来抑制胶原蛋白的分泌。Col003 可用于肺纤维化的相关研究。
研究领域：Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点：HSP
In Vitro: Col003 (4.4-40 μM) is cleaved from Col001 (AK-778). Col003 has an inhibitory effect on the interaction of Hsp47 with collagen in Hsp47 KO ?/? MEFs.
?Col003 (0.01-100 μM) exhibits dose-dependent effects on the interactions of Hsp47 with collagen. The IC50?value is 1.8 μM for Hsp47.
?Col003 (100 μM; 20-60 mins) has an nhibitory effects on collagen secretion and accumulation. It inhibits collagen secretion by wild-type MEFs and the secretion is not abolished completely.
?Col003 (100 μM) degrades α,α′-dipyridyl collagen secretion completely by incubation with trypsin at a high temperature (50 °C for 15 min), but it resistant to trypsin digestion at 37 °C.
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