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- 2025年12月05日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1818389-84-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1005.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥409.0 |
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 25 mg | 产品价格： | ￥2225.0 |
| 规格： | 50 mg | 产品价格： | ￥3500.0 |
| 规格： | 100 mg | 产品价格： | ￥5500.0 |
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SPHINX31
CAS No. : 1818389-84-2
MCE 国际站：SPHINX31
产品活性：SPHINX31 是一种有效的、丝氨酸/富含精氨酸的蛋白激酶1 (SRPK1) 的选择性抑制剂，其IC50 值为 5.9 nM。SPHINX31 能够抑制富丝氨酸/精氨酸剪接因子 1 (SRSF1) 的磷酸化。SPHINX31 还能降低促血管生成基因 VEGF-A165a 亚型的 mRNA 表达。SPHINX31 可用于研究新生血管性眼病。
研究领域：Cell Cycle/DNA Damage | Protein Tyrosine Kinase/RTK
In Vitro: SPHINX31 (0.3-10 μM; 24 h) significantly down-regulates the expression of VEGF-A165a mRNA.
SPHINX31 (0.3 μM; 24 h) suppresses SRSF1 phosphorylation and nuclear localization.
SPHINX31 (0.3-10 μM; 24 h) decreases pre-tube formation and the rate of migration for human umbilical vein endothelial cells (HUVECs).
In Vivo: SPHINX31 (200 μg/mL; twice daily topical eye drops) protects the retinal endothelial permeability barrier from diabetes-associated loss of integrity.
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