T-448,1597426-53-3

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T-448

CAS No. : 1597426-53-3

MCE 国际站：T-448

产品活性：T-448 是赖氨酸特异性去甲基化酶1 (LSD1，一种H3K4去甲基化酶) 不可逆的、口服有效的抑制剂，IC₅₀ 值为 22 nM。T-448能够加强原代培养的大鼠神经元中H3K4的甲基化。

研究领域：Epigenetics

作用靶点：Histone Demethylase

In Vitro: T-448 enhances the levels of H3K4 methylation, increased mRNA expression of neural plasticity-related genes including brain derived neurotrophic factor (Bdnf), and ameliorated learning dysfunction.

In Vivo: T-448 has minimal impact on the LSD1-GFI1B complex and a superior hematological safety profile in mice via the generation of a compact formyl-FAD adduct. T-448 increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction.
T-448 increases H3K4 methylation in the brain without causing hematological side effects even at 100 mg/kg.

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