Human CCL17 also known as thymus and activation-related chemokine(TARC)is encoded by the CCL17 gene located on the chromosome 16 in humans.It is expressed by thymus cells constitutively and phytohemagglutinin-stimulated peripheral blood mononuclear cells transiently.CCL17 signals through the chemokine receptors CCR4 and CCR8 and displays chemotactic activity for T lymphocytes and some other leukocytes.It plays an important role in skin diseases such as atopic dermatitis,bullous pemphigoid and mycosis fungoides.CCL17 has approximately 24 – 29%amino acid sequence identity with RANTES,MIP-1α,MIP-1β,MCP-1,MCP-2,MCP-3 and I-309.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
外观
Sterile Filtered White lyophilized(freeze-dried)powder.
纯度
>97%by SDS-PAGE and HPLC analyses.
来源
Escherichia coli.
生物活性
Fully biologically active when compared to standard.The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10ng/ml.
成分
Lyophilized from a 0.2μmfiltered concentrated solution in 20mMPB,pH 7.4,150mM NaCl.
内毒素
Less than 1 EU/μg of rHuTARC/CCL17 as determined by LAL method.
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列
ARGTNVGREC CLEYFKGAIP LRKLKTWYQT SEDCSRDAIV FVTVQGRAIC SDPNNKRVKN AVKYLQSLER S
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