AE-3763

AE-3763

MCE 国际站：AE-3763

产品活性：AE-3763 是基于多肽的人中性粒细胞弹性蛋白酶 (human neutrophil elastase) 抑制剂，IC₅₀ 值为29 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Elastase

In Vitro: AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.

In Vivo: Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED₅₀: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv.

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