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- 2025年12月05日
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Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥900.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥516.0 |
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1810.0 |
| 规格： | 25 mg | 产品价格： | ￥3800.0 |
| 规格： | 50 mg | 产品价格： | ￥5510.0 |
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AS1949490
CAS No. : 1203680-76-5
MCE 国际站：AS1949490
产品活性：AS1949490 是一种口服有效的选择性 SHIP2 磷酸酶抑制剂，抑制小鼠 SHIP2、人 SHIP2、人 SHIP1、人 PTEN、人突触小泡磷酸酶和人肌管蛋白的 IC50 值分别为 0.34、0.62、13、>50、>50 和 >50 µM。AS1949490 增加 Akt 的磷酸化、葡萄糖的消耗和葡萄糖的摄取。AS1949490 激活细胞内胰岛素信号通路。AS1949490 可用于糖尿病的研究。
研究领域：Metabolic Enzyme/Protease | PI3K/Akt/mTOR
作用靶点：Phosphatase | Akt
In Vitro: AS1949490 (0-16 μM; 15 min; L6 myotubes) increases insulin-induced phosphorylation of Akt.
?AS1949490 (0-10 μM; 48 h) activates glucose metabolism and stimulates glucose uptake activity in L6 myotubes.
?AS1949490 (0-10 μM; 24 h; L6 myotubes) decreases the level of insulin-induced gluconeogenesis.
?AS1949490 (10 μM; 48 h) activates glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes.
In Vivo: AS1949490 (300 mg/kg; p.o.; twice daily, for 7 or 10 d) decreases plasma glucose and activates intracellular insulin signalling in diabetic mice.?AS1949490 (300 mg/kg; p.o.; once, for 8 h; male ICR mice) suppresses gluconeogenesis and the expression of related genes.
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