Stattic,19983-44-9

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Stattic

CAS No. : 19983-44-9

MCE 国际站：Stattic

产品活性：Stattic 是一种有效的 STAT3 抑制剂，可以抑制 STAT3 磷酸化 (磷酸化位点为 Y705 和 S727)。Stattic 抑制高亲和力磷酸肽与 STAT3 的 SH2 域结合。Stattic 可改善 Alport 综合征 (AS) 小鼠的肾功能不全。

研究领域：JAK/STAT Signaling  |  Stem Cell/Wnt  |  Apoptosis

作用靶点：STAT  |  Apoptosis

In Vitro: Stattic (20 μM; 24 hours) inhibits STAT3 phosphorylation (Y705) and selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in ALDH⁺ and D44⁺/CD24⁺ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines.
?Stattic (2.5, 5, 10 μM; for 4 h) significantly reduces the nuclear level of pSTAT3 and survivin in PC3M-1E8 cells at 10 μM. Stattic (2.5-10 μM; for 24 h) inhibits IL-6-induced STAT3 activation in a dose-dependent manner.
?Stattic (2.5, 5, 10 μM; for 48 h) suppresses both the growth and induces apoptosis prostate cancer cells (PC3M-1E8 cells) with 10 μM. Stattic does not induce significant cell apoptosis with 2.5 μM, 5 μM.
?Stattic (2.5, 5, 10 μM; for 48 h) shows significant S phase accumulation.
?Stattic can not lead to significant morphological changes or apoptosis and has little STAT3 phosphorylation in A2780 cells and HUVECs.

In Vivo: Stattic (10 mg/kg; i.p.; three times per week for 10 week) ameliorates the renal dysfunction in Alport syndrome (AS) mice.

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