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CD31 Rabbit pAb, APC conjugate

d(bs-0195R-APC)-100ul
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  • bs-0195R-APC
  • 2025年10月15日
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      100ul

    产品编号bs-0195R-APC
    英文名称CD31 Rabbit pAb, APC conjugated
    中文名称APC标记的血小板内皮细胞黏附分子1抗体
    英文别名platelet endothelial cell adhesion molecule precursor-1; PECAM-1; PECAM1; Adhesion molecule; CD31 antigen; CD31 EndoCAM; Endocam; FLJ34100; FLJ58394; GPIIA; Pecam 1; PECA1_HUMAN; PECAM 1 CD31 EndoCAM; PECA1; Pecam1; Platelet endothelial cell adhesion molecule; Platelet/endothelial cell adhesion molecule 1; Adhesion molecule; Platelet/endothelial cell adhesion molecule.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human CD31
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚基

    Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction (PubMed:26702061, PubMed:27958302).
    Forms a complex with BDKRB2 and GNAQ (PubMed:18672896).
    Interacts with BDKRB2 and GNAQ (PubMed:18672896).Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment (PubMed:18388311, PubMed:19342684).
    Interacts with FER (By similarity).
    Interacts (via Ig-like C2-type domain 6) with CD177; the interaction is Ca2+-dependent; the interaction is direct (PubMed:17580308).

    亚细胞定位

    Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

    组织特异性

    Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369).
    Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308).
    Expressed on neutrophils (at protein level) (PubMed:17580308).
    Isoform Long predominates in all tissues examined (PubMed:12433657).
    Isoform Delta12 is detected only in trachea (PubMed:12433657).
    Isoform Delta14-15 is only detected in lung (PubMed:12433657).
    Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657).
    Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).

    翻译后修饰

    Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation. In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation.

    相似性

    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

    功能

    Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308).
    Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).
    Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302).
    Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308).
    Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neiGHBoring viable leukocytes by transmitting a detachment signal (PubMed:12110892).
    Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892).
    Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896).
    Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896).
    Induces susceptibility to atherosclerosis (By similarity).

    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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      该产品被引用文献

      [IF={{ 8.7 }}] {Di Wu. et al.Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury.mater today bio.2025 Jan 30:31:101528.} {Flow cytometry} {Rat}

      [IF={{ 5.046 }}] {Di Wu. et al. Immunomagnetic Delivery of Adipose-Derived Endothelial Progenitor Cells for the Repair of Renal Ischemia–Reperfusion Injury in a Rat Model. Bioengineering-Basel. 2023 May;10(5):509} {IF} {Rat}

      [IF={{ 3.989 }}] {Zhang C et al. CXCR4-Overexpressing Umbilical Cord Mesenchymal Stem Cells Enhance Protection against Radiation-Induced Lung Injury. Stem Cells Int. 2019 Feb 5;2019:2457082.} {FCM} {Human}

      [IF={{ 10.2 }}] {Fei Sun. et al. In Situ Vascularization and Epithelialization of Segmental Bioengineered Trachea Based on Marrow-Derived Stem/Progenitor Cells. MATER TODAY BIO. 2025 Jun;:101990} {FC} {Rabbit}

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      • Fluorochrome Absorption and Emission Spectra

        light at 488 nm for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes

      • Fluorochrome Absorption and Emission

        for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes are useful in experiments

      • 抗癌药物的自述

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      CD31 Rabbit pAb, APC conjugated(bs-0195R-APC)-100ul
      ￥2980