重组人FGF-21北京供应商

特别提示：包括重组人FGF-21在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人FGF-21
英文名称：Recombinant Human Fibroblast Growth Factor-21
产品货号：GS4454
产品规格：5μg

分子量：Approximately 19.4kDa,a single non-glycosylated polypeptide chain containing 181 amino acids.
储存条件：冷冻（-20℃）

概述

Fibroblast growth factor-21(FGF-21)belongs to the large FGF family which is encoded by the FGF-21 gene and it is specifically induced by HMGCS2 activity.All FGF family members are heparin binding growth factors with a core 120 amino acid(a.a.)FGF domain that allows for a common tertiary structure and they are involved in a variety of biological processes including embryonic development,cell growth,morphogenesis,tissue repair,tumor growth and invasion.FGF-21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression(but not SLC2A4/GLUT4 expression)and the activity depends on the presence of KLB.FGF-21 contains a 28 a.a.signal sequence and a 181 a.a.mature region but show limited binding to heparin.In addition,Mature human FGF-21 respectively shows 81%a.a.identity to murine and rat FGF-21,and is known to be active on murine cells.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞96%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5μg/ml,corresponding to a specific activity of>2.0×103 IU/mg in the presence of 5μg/ml of rMuKlotho-β and 10 μg/ml of heparin.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuFGF-21 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA S

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