重组人p16-INK4a北京品牌

特别提示：包括重组人p16-INK4a在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人p16-INK4a
英文名称：Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A, Isoform 1
产品货号：GS4830
产品规格：10μg

分子量：Approximately 16.5kDa,a single non-glycosylated polypeptide chain containing 156 amino acids.
储存条件：冷冻（-20℃）

概述

Cyclin-dependent kinase inhibitors(CDKIs)are proteins that bind to and inhibit the activity of CDKs.Two major classes of CDK inhibitors have been identified.The p16 family(p15,p16,p18 and p19)binds to and inhibits the activities of CDK4 and CDK6.The p21 family(p21,p27,p28 and p57)can bind to broad range of CDK-cyclin complexes and inhibit their activities.CDKIs are capable of suppressing growth,and several lines of evidence strongly suggest that at least some CDKIs may be tumor suppressor proteins.p16-INK4A is the member of p16 family and is encoded by CDKN2A gene in humans.It has three isoforms,which are wildly expressed but not detected in brain or skeletal muscle,except that isoform 3 is pancreas-specific.Defects in p16INK4A are a cause of Li-Fraumeni syndrome(LFS)and melanoma-astrocytoma syndrome(MASTS).

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞96%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Data Not Available.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuP16-INK4a as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD

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