重组小鼠IL-33北京价格

特别提示：包括重组小鼠IL-33在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠IL-33
英文名称：Recombinant Murine Interleukin-33
产品货号：GS4487
产品规格：2μg

分子量：Approximately 17.5kDaprotein containing 158 amino acid residues.
储存条件：冷冻（-20℃）

概述

IL-33 is a number of IL-1 superfamily,secreted by high endothelial venules at high levels,which is found in tonsils,peyer patches and mesenteric lymph nodes,but not in placenta.It elicits its biological effects by interacting with IL1RL1/ST2 and its stimulation recruits MYD88,IRAK1,IRAK4,and TRAF6,followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2,MAPK14,and MAPK8.IL-33 induces production of TH2 cell related cytokines,including IL-4,IL-5 and IL-13,and exerts multiple inflammation related bioactivities.Mature IL-33 share approximately 55%and 90%a.a.sequence identity with human and rat IL-33 respectively.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞98%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5ng/ml,corresponding to a specific activity of>2.0×106 IU/mg.
成分	Lyophilized from a 0.2μmfiltered solution in PBS,and 1mMEDTA.
内毒素	Less than 1 EU/μg of rMuIL-33 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI

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