重组人IL-13,Variant北京品牌

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产品名称：重组人IL-13,Variant
英文名称：Recombinant Human Interleukin-13, Variant
产品货号：GS4479
产品规格：2μg

分子量：Approximately 12.3kDa,a single non-glycosylated polypeptide chain containing 112 amino acids,with a substitution of Q for R at position 112 compared with the wild type IL-13.
储存条件：冷冻（-20℃）

概述

Human Interleukin-13(IL-13)is expressed by the IL13 gene located on the chromosome 5.IL-13 is a 132 amino acid protein containing a proposed 20 amino acid signal peptide,and shares approximately 30%amino acid sequence homology to human IL-4.Additionally,the two cytokines exhibit overlapping biological activities.Human IL-13 is produced by activated Th0,Th1-like Th2-like and CD8 T cells.Similarly to IL-4,IL-13 has multiple effects on the differentiation and functions of monocytes/macrophages.IL-13 can suppress the cytotoxic functions of monocytes/macrophages.IL-13 variant is a natural variant of IL-13 and has a Q instead of R112 of wild type,which associated with increased risk for asthma development and at homozygosity associated with higher levels of serum total IgE in some allergic rhinitis patients.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5ng/ml,corresponding to a specific activity of>2.0×106 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.2,with 5%trehalose.
内毒素	Less than 1 EU/μg of rHuIL-13,Variant as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGQ FN

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