重组人泛素样蛋白(ISG15)北京供应商

特别提示：包括重组人泛素样蛋白(ISG15)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人泛素样蛋白(ISG15)
英文名称：Recombinant Human Interferon-stimulated Gene 15
产品货号：JN0883
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Gly2-Gly157在C端含有His标签。

ISG15质量控制：＞95%(还原性SDS-PAGE)

ISG15制剂：液体

ISG15保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于ISG15：
Ubiquitin-Like Protein ISG15 is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. ISG15 becomes conjugated to a diverse set of proteins after IFN-alpha/beta stimulation or microbial challenge.The functions or biochemical consequences ISG15 conjugation to proteins are not yet known, but it appears that this modification does not target proteins for proteasomal degradation.ISG15 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. Upon interferon treatment, ISG15 can be detected in both free and conjugated forms, and is secreted from monocytes and lymphocytes where it can function as a cytokine. In the cell, ISG15 co-localizes with intermediate filaments and ISGylation may modulate the JAK-STAT pathway or certain aspects of neurological disease.

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