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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
(Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
68047-06-3
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥639.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥750.0 |
| 规格： | 10 mg | 产品价格： | ￥950.0 |
| 规格： | 25 mg | 产品价格： | ￥2050.0 |
| 规格： | 50 mg | 产品价格： | ￥4000.0 |
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4-Hydroxytamoxifen
CAS No. : 68047-06-3
MCE 国际站：4-Hydroxytamoxifen
产品活性：4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) 是一种口服有效，选择性的雌激素受体调节剂 (SERM)。4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) 基于 ER 介导的细胞核易位诱导 CRISPR/Cas9 系统。
研究领域：Vitamin D Related/Nuclear Receptor
作用靶点：Estrogen Receptor/ERR
In Vitro: 4-Hydroxytamoxifen (Monohydroxytamoxifen) is a selective ostrogen receptor antagonist, with an IC50 of 3.3 nM for the [3H]oestradiol binding to oestrogen receptor. 4-Hydroxytamoxifen (10, 100 nM) enables to inhibit the binding of [3H]oestradiol to the human 8 S oestrogen receptor.
4-Hydroxytamoxifen activates intein-linked inactive Cas9, reduces off-target CRISPR-mediated gene editing. In human cells, conditionally active Cas9s modify target genomic sites with up to 25-fold higher specificity than wild-type Cas9.
In Vivo: 4-Hydroxytamoxifen (0.2, 1 and 5 μg/day, p.o.) causes a dose-related decrease in uterine wet weight of immature rats.
4-Hydroxytamoxifen (6 μg/0.1 mL sesame oil/day, s.c.) effectively attenuates methamphetamine-induced nigrostriatal dopamine depletions in bothsexes of intact and gonadectomized C57BL/6 J mice. 4-Hydroxytamoxifen does not alter the dopamine content levels in the striatum.
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文献和实验Fate Tracing of neurogenin2-Expressing Cells in the Mouse Retina Using CreER: LacZ
requires the removal of “stop” by Cre recombinase (Wagner et al. Transgenic Res 10:545–553, 2001). 4-hydroxytamoxifen (4-OHT), a synthetic ligand with high affinity for ER™ , is administered to double transgenic embryos and/or neonatal mice. Binding
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