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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1629063-78-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1613.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥498.0 |
| 规格： | 5 mg | 产品价格： | ￥1400.0 |
| 规格： | 10 mg | 产品价格： | ￥2300.0 |
| 规格： | 25 mg | 产品价格： | ￥3650.0 |
| 规格： | 50 mg | 产品价格： | ￥5400.0 |
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Ibiglustat (L-Malic acid)
CAS No. : 1629063-78-0
MCE 国际站：Ibiglustat (L-Malic acid)
产品活性：Ibiglustat (Venglustat) L-Malic acid 是一种具有口服活性的，可透过血脑屏障的葡萄糖神经酰胺合成酶 (GCS) 抑制剂。Ibiglustat (Venglustat) L-Malic acid 可用于研究戈谢病 3 型、与 GBA 突变相关的帕金森病、法布瑞氏症、GM2 神经节苷脂病和常染色体显性多囊肾病。
研究领域：Neuronal Signaling
作用靶点：Glucosylceramide Synthase (GCS)
In Vitro: Ibiglustat (SAR402671) (1 μM, 15 days) L-Malic acid treated Fabry disease (FD) cells are close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat L-Malic acid can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Neuronal Signaling Compound Library | Clinical Compound Library | CNS-Penetrant Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Lipid Metabolism Compound Library | Rare Diseases Drug Library | Heterocyclic Compound Library | Ibiglustat | Miglustat hydrochloride | Lucerastat | Glucosylceramide synthase-IN-2 | D-threo-PPMP hydrochloride | Sinbaglustat | Glucosylceramide synthase-IN-1 | AMP-Deoxynojirimycin | D-threo-PDMP | Fucosyltransferase 8 | G43 | G43-C3-TEG | Genz-123346 | Glucosylceramide synthase-IN-3 | Nizubaglustat | PDMP hydrochloride | UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2 | α-N-Acetylglucosaminidase
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