PCI-27483,871266-63-6

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PCI-27483

CAS No. : 871266-63-6

MCE 国际站：PCI-27483

产品活性：PCI-27483 是 FVIIa/tissue factor 抑制剂，具有抗肿瘤的活性。

研究领域：Others

作用靶点：Others

In Vitro: PCI-27483 inhibits the TF:FVIIa-complex induced phosphorylation of ERK1/2 and subsequent induction of c-fos in BxPC3 cells, a human pancreatic adenocarcinoma line that highly expresses TF. Furthermore, PCI-27483 blocks the TF:FVIIa induced secretion of IL8 in both BxPC3 cells and MDA-MB-231 breast cancer cells.

In Vivo: PCI-27483 shows dose-dependent inhibition of thrombus formation, fibrin accumulation and PT. PCI-27483 (4 mg/kg) shows comparable anticoagulation effects as 2 mg/kg enoxaparin. PCI-27483 (0 and 90 mg/kg, s.c.) results in inhibition of tumor growth in CD1 nu/nu mice implanted with BxPC3 cells.

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