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- 2025年12月05日
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货期：询盘
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MedChemExpress LLC
- CAS号：
136719-25-0
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询盘
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NB-598 hydrochloride
CAS No. : 136719-25-0
MCE 国际站：NB-598 hydrochloride
产品活性：NB-598是鲨烯环氧化酶（SE）竞争性抑制剂，能抑制甘油三酯的生物合成。
研究领域：Others
作用靶点：Others
In Vitro: NB598 (10 μM) causes a 36±7% reduction in total cholesterol level of MIN6 cells. NB598 causes a significant decrease in cholesterol by 49±2%, 46±7%, and 48±2% from PM, ER, and SG, respectively. NB598 dose-dependently inhibits insulin secretion under both basal (1 mM glucose) and glucose-stimulated (16.7 mM glucose) conditions. NB598 at concentrations up to 10 μM does not affect peak outward KV currents or the voltage dependence of activation but increases current inactivation. NB-598 (10 μM) inhibits the synthesis of sterol and sterol ester from [14C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). In the absence of exogenous liposomal cholesterol, NB-598 reduces ACAT activity by 31%. NB-598 reduces ACAT activity by 22% even in the presence of a 600 PM concentration of liposomal cholesterol. NB-598 suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells into the medium.
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文献和实验Isolation of cell nuclei for the application in the cell-free system
- PROCEDURE Grow cells in a 160 cm2 flask (25 ml medium) up to about 75% cell density. Remove medium from the cell culture flask except 5 ml. To the remaining 5 ml add 25 µl of 4.2 mM Cytochalasin B (CB); Incubate 30 min at 37°C (cells
5.598 7.173 8.610 5 0.727 1.476 2.015 2.571 3.365 4.032 4.773 5.893 6.869 6 0.718 1.440 1.943 2.447 3.143 3.707 4.317 5.208 5.959 7 0.711 1.415 1.895 2.365 2.998 3.499 4.029 4.785 5.408 8 0.706 1.397 1.860 2.306 2.896 3.355 3.833
禁食 16 小时就可以唤醒身体「时钟」！Cell 子刊揭示间歇性禁食有益健康的关键节点
部位——肝脏、肌肉、白色脂肪、棕色脂肪，为间歇性禁食的研究领域提供了全面而关键的数据。 该研究锚定小鼠代谢组织 24 小时内的时空转录通路谱图，结果显示 95.6% 被检测到的典型通路具有组织特异性和喂养方案特异性的节律变化，然而只有不到 25% 的通路诱导全天转录功能的改变。同时，他们发现禁食 16 小时触发了肝脏中许多典型通路的明显切换效应，而其他代谢组织内并没有观察到相应现象。一旦该效应启动，波谷和峰值将会在接下来的再进食和禁食中准时出现。 图片来源：Cell Reports 肝脏
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