p16 Polyclonal Antibody_货号:E-A

Verified Samples in IHC:Rat liver,Human ovarian
Verified Samples in IF:PC-3

IHC 1:50-1:200 , IF 1:100-1:200

Polyclonal

IgG

Recombinant Rat Cyclin-dependent kinase inhibitor 2A protein

p16

CCM2;CDK4 inhibitor p16 INK4;CDK4I;CDKN2;CDKN2A;Cell cycle negative regulator beta;CMM2;Cyclin dependent kinase 4 inhibitor A;Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4);Cyclin Dependent Kinase Inhibitor 2A抗体

Q9R0Z3

Cytoplasm,?Nucleus

0.82 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Antigen Affinity Purification

Cancer; Cell Biology; Epigenetics and Nuclear Signaling

Unconjugated

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.