NFAT2 Polyclonal Antibody_货号:E

Verified Samples in WB:Jurkat,U87-MG,K562
Verified Samples in IHC:Rat brain,Human tonsil,Mouse brain,Human placenta

WB 1:500-1:3000, IHC 1:50-1:200

Polyclonal

IgG

Recombinant fusion protein of human NFAT2 (NP_765978.1).

NFAT2

NF-ATC;NF-ATc1.2;NFAT2;NFATc;NFATC1抗体

O95644

38kDa/74- 88kDa/100-101kDa

78kDa

Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

1mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Affinity purification

Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Immunology; Signal Transduction

Unconjugated

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.