- ￥1580 - 4020
- Elabscience
- E-AB-62227
- 武汉
- 2026年03月25日
- WB;IF
- Rabbit
- Human;Mouse;Rat
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从原料到标记，打造属于中国自己的流式抗体品牌abinScience 体内级抗体，年度锁价，低至 1200五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
(KO Validated) STAT3 Polyclonal Antibody_货号:E-AB-62227_多克隆抗体
- 抗体英文名：
(KO Validated) STAT3 Polyclonal Antibody
- 靶点：
STAT3
- 浓度：
5 μL/Test
- 应用范围：
WB;IF
- 宿主：
Rabbit
- 适应物种：
Human;Mouse;Rat
- 保质期：
12个月
- 级别：
科研
- 库存：
99
- 供应商：
武汉伊莱瑞特生物科技股份有限公司
- 标记物：
0
- 克隆性：
Polyclonal
- 保存条件：
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
- 形态：
液体
- 亚型：
IgG
- 规格：
200μL/120μL/60μL
| 规格： | 200μL | 产品价格： | ￥4020.0 |
|---|---|---|---|
| 规格： | 120μL | 产品价格： | ￥2520.0 |
| 规格： | 60μL | 产品价格： | ￥1580.0 |
货号：E-AB-62227
| Verified Samples |
Verified Samples in WB:HeLa,HeLa,293T
Verified Samples in IF:Rat brain,Mouse brain |
| Dilution |
WB 1:500-1:2000, IF 1:50-1:200
|
| Clonality |
Polyclonal
|
| Isotype |
IgG
|
| Immunogen |
Recombinant fusion protein of human STAT3 (NP_644805.1).
|
| Abbre |
STAT3
|
| Synonyms |
ADMIO;ADMIO1;APRF;HIES;STAT3;Stat3 抗体
|
| Swissprot |
P40763
|
| Calculated MW |
83kDa/87kDa/88kDa
|
| Observed MW |
90kDa
|
| Cellular Localization |
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
|
| Concentration |
1mg/mL
|
| Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
| Buffer |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
|
| Purification Method |
Affinity purification
|
| Research Areas |
Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Developmental Biology; Signal Transduction; Stem Cells
|
| Conjugation |
Unconjugated
|
| Background |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
|
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文献和实验Leptin Selectively Regulates Nutrients Metabolism in Nile Tilapia Fed on High Carbohydrate or High Fat Diet
IF:3.519
Journal:Frontiers in Endocrinology
DOI:10.3389/fendo.2018.00574
Construction of Polyclonal Antibody Libraries Using Phage Display
Polyclonal antibody libraries (PCALs) are standardized mixtures of antibodies (Abs) specific for an antigen (Ag) or multi-Ag target (a poly-Ag). As the immunoglobulin (Ig) genes are cloned, the mixtures can be perpetuated, amplified
and how they were validated for use in the system under study （i.e. assay and species）。类似对抗体验证（抗体特异性）的质疑不再仅限于 science，nature 等高分杂志，由于生物试剂普遍存在的特异性问题导致实验结果不可重复1，已经引起主流学术期刊的关注。编辑们正逐渐提高对抗体特异性问题的重视，并要求提供抗体特异性的证据。事实上，抗体的特异性问题，就是我们常说的「脱靶」。市面上抗体的品质良莠不齐，有相当一部分抗体并不能正确识别您想研究的靶标。想想是不是
因此，综合来说，EarthOx的GST标签抗体 （货号#E022040）是一款同时具有高特异性、高灵敏度、多应用类型以及性价比的GST标签抗体。同时，我们也提供其他品牌的GST标签抗体，如Proteintech的GST多克隆抗体 ――GST PolyClonal Antibody（货号#10000-0-AP）以及Abcam、Santa等多种GST标签抗体产品。更多GST标签抗体以及其他如His、HA、Myc、GFP、Flag等其他标签抗体，请电话垂询。美国EarthOx品牌是一家提供高性价比免疫学和细胞
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