CASP1 Polyclonal Antibody_货号:E

Verified Samples in WB:MCF-7,THP-1,Mouse spleen,Mouse thymus,Rat spleen,Rat lung,Rat thymus
Verified Samples in IHC:Human tonsil,Human lung cancer,Human liver cancer

WB 1:500-1:2000, IHC 1:300-1:800

Polyclonal

IgG

Recombinant protein corresponding to Mouse Caspase1

CASP1

CASP-1;CASP1;CASP1;Caspase 1;Caspase-1 subunit p10;ICE;IL-1 beta-converting enzyme;IL-1BC;IL1 beta converting enzyme;IL1B convertase;Interleukin 1 beta convertase;Interleukin 1B converting enzyme;Interleukin-1 beta convertase;Interleukin-1 beta-converting enzyme;p45抗体

P29466,P29452,P43527

45kDa

45-47kDa,30kDa,35kDa

Cytoplasm.

1.2 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Affinity purification

Cancer; Cell Biology; Metabolism

Unconjugated

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.